{"id":13751,"date":"2020-04-03T14:24:46","date_gmt":"2020-04-03T12:24:46","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=13751"},"modified":"2020-04-03T14:19:31","modified_gmt":"2020-04-03T12:19:31","slug":"mes-a-prop-de-coneixer-els-mecanismes-moleculars-amagats-rere-els-records","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/mes-a-prop-de-coneixer-els-mecanismes-moleculars-amagats-rere-els-records\/","title":{"rendered":"M\u00e9s a prop de con\u00e8ixer els mecanismes moleculars amagats rere els records"},"content":{"rendered":"

Gr\u00e0cies a la combinaci\u00f3 de dues prote\u00efnes, els ARN missatgers (ARNm) que codifiquen per dos components de l’esquelet cel\u00b7lular \u2014 actina i tubulina\u00a0\u2014\u00a0<\/span>poden viatjar cap a les sinapsis, on es tradueixen a prote\u00efnes i afavoreixen la\u00a0formaci\u00f3 i emmagatzematge de mem\u00f2ria a llarg termini<\/strong>.<\/p>\n

Aquest \u00e9s el recent descobriment<\/a> realitzat per personal investigador del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, que revela per primer cop com les\u00a0neurones<\/strong> transporten<\/strong>, al lloc indicat, la\u00a0informaci\u00f3 <\/strong>essencial pel seu creixement i moviment. Aquest proc\u00e9s \u00e9s especialment important durant el desenvolupament del cervell, doncs ajuda a les neurones a trobar el seu lloc en aquest \u00f2rgan, aix\u00ed com durant la creaci\u00f3 de la mem\u00f2ria.<\/p>\n

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\u00abEstimular les sinapsis repetidament refor\u00e7a la connexi\u00f3 i es creu que \u00e9s aix\u00ed com es creen els records\u00bb<\/p><\/blockquote>\n

 <\/p>\n

Els components del citoesquelet necessaris per les sinapsis hi arriben no en forma de prote\u00efnes, sin\u00f3 com a ARNm, que s\u00f3n tradu\u00efts a prote\u00efnes a posteriori<\/em>, quan \u00e9s necessari. Fins el moment es creia que les quinesines<\/strong>, les prote\u00efnes m\u00e9s comunes a l’hora de transportar mol\u00e8cules, eren les encarregades d’enviar, en les neurones, els ARNm al lloc adequat i en el temps indicat. No obstant, els investigadors i investigadores del CRG han pogut confirmar gr\u00e0cies al seu estudi que la\u00a0quinesina KIF3A\/B<\/strong>\u00a0transporta l’ARNm gr\u00e0cies a la seva combinaci\u00f3 amb la prote\u00efna adaptadora\u00a0Adenomatous Polyposis Coli<\/em> (APC)<\/strong>. Ambdues prote\u00efnes\u00a0\u2014 KIF3A\/B i APC\u00a0\u2014 transporten com a m\u00ednim dos tipus d’ARNm que codifiquen per\u00a0tubulina<\/strong> i\u00a0actina<\/strong>, components essencials del citoesquelet, o esquelet cel\u00b7lular. L’esquelet cel\u00b7lular<\/strong> \u00e9s l’encarregat de donar forma a les c\u00e8l\u00b7lules i, a les neurones, permet establir noves connexions.<\/p>\n

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\"\"<\/p>\n

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A estudis anteriors, ja s’havia comprovat que la informaci\u00f3 gen\u00e8tica en forma d’ARNm de la prote\u00efna\u00a0\u03b2-actina viatja cont\u00ednuament a les sinapsis<\/b>. Un cop all\u00e0, gr\u00e0cies a l’estimulaci\u00f3 repetida de les sinapsis, l’ARNm \u00e9s tradu\u00eft a la prote\u00efna\u00a0\u03b2-actina, encarregada de refor\u00e7ar la connexi\u00f3. Es creu que \u00e9s aix\u00ed com es formen els records. Aquest nou estudi del CRG descriu com l’ARNm \u00e9s transportat.<\/p>\n

\u00abContinuarem investigant els sistemes de transport neuronals. Comprendre la maquin\u00e0ria que ajuda al desenvolupament neuronal \u00e9s clau per combatre reptes globals tals com les\u00a0malalties neurodegeneratives<\/strong>\u00ab, conclou l’autor principal de l’estudi i investigador del CRG, Sebastian Mauer.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Personal investigador del CRG descobreix com les neurones envien informaci\u00f3 gen\u00e8tica al lloc i en el temps adequats. Aquest procediment \u00e9s essencial per a la creaci\u00f3 i emmagatzematge dels records a llarg termini.<\/p>\n","protected":false},"author":9,"featured_media":13731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[555,297,263,265,708,219,317,406,329],"new-type":[35],"class_list":["post-13751","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-arn","tag-biologia-molecular","tag-cervell","tag-crg-ca","tag-genetica","tag-microtubuls","tag-neurobiologia","tag-neurodesenvolupament","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=13751"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13751\/revisions"}],"predecessor-version":[{"id":13834,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13751\/revisions\/13834"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/13731"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=13751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=13751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=13751"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=13751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}