{"id":13364,"date":"2020-03-25T15:58:36","date_gmt":"2020-03-25T14:58:36","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=13364"},"modified":"2020-03-25T15:58:36","modified_gmt":"2020-03-25T14:58:36","slug":"cap-a-la-generacio-de-cel%c2%b7lules-mare-de-la-sang-al-laboratori","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/cap-a-la-generacio-de-cel%c2%b7lules-mare-de-la-sang-al-laboratori\/","title":{"rendered":"Cap a la generaci\u00f3 de c\u00e8l\u00b7lules mare de la sang al laboratori"},"content":{"rendered":"<p>Poder<strong> generar <a href=\"https:\/\/ellipse.prbb.org\/ca\/cel%c2%b7lules-mare-generacio-i-regeneracio\/\" target=\"_blank\" rel=\"noopener\">c\u00e8l\u00b7lules mare<\/a> de la sang al laboratori<\/strong> ser\u00eda un pas enorme en el camp de la medicina regenerativa, i concretament en el <strong>tractament de pacients amb malalties com la leuc\u00e8mia<\/strong> o patologies gen\u00e8tiques que afecten la sang i que no tenen un donant compatible.<\/p>\n<p>Aquesta imatge pertany a un recent estudi que podr\u00eda obrir noves opcions en aquest sentit. En ella, es pot observar la <strong>reconstrucci\u00f3 d&#8217;una aorta d&#8217;embri\u00f3 de ratol\u00ed (en lila) on s\u2019estan formant c\u00e8l.lules de la sang (verd)<\/strong> que van cap al lumen del vas sanguini.<\/p>\n<p>\u201cFins ara s\u2019havien pogut generar diferents tipus de c\u00e8l\u00b7lules del sistema sanguini, com eritr\u00f2cits o plaquetes, per\u00f2 no s&#8217;ha aconseguit fer mai una c\u00e8l\u00b7lula que tingui caracter\u00edstiques de c\u00e8l\u00b7lula mare de la sang\u00bb, explica<a href=\"https:\/\/ellipse.prbb.org\/ca\/anna-bigas-grup-de-recerca-en-cel%c2%b7lules-mare-i-cancer\/\" target=\"_blank\" rel=\"noopener\"><strong> Anna Bigas<\/strong><\/a>, coordinadora del grup\u00a0<a href=\"http:\/\/imim.acblnk.com\/url\/ver\/45310646\/940650\/0e96bbe82ff7219332acfb39006aaaf7\" target=\"_blank\" rel=\"noopener\">de recerca en c\u00e8l\u00b7lules mare i c\u00e0ncer<\/a>\u00a0de l&#8217;<a href=\"http:\/\/www.imim.es\/\" target=\"_blank\" rel=\"noopener\">Institut Hospital del Mar d\u2019Investigacions M\u00e8diques\u00a0(IMIM)<\/a> i <strong>l\u00edder de l\u2019estudi<\/strong>.<\/p>\n<p><a href=\"https:\/\/www.imim.es\/noticies\/872\/descobreixen-una-de-les-peces-clau-per-generar-cel%C2%B7lules-mare-de-la-sang-a-laboratori\" target=\"_blank\" rel=\"noopener\">L\u2019equip investigador ha analitzat<\/a>, en embrions de ratolins i amb models computacionals, el proc\u00e9s pel qual les c\u00e8l\u00b7lules de l&#8217;endoteli, el teixit que recobreix la part interna de tots els vasos sanguinis, es converteixen en c\u00e8l\u00b7lules mare de la sang. I han pogut comprovar que <strong>la interacci\u00f3 entre dues mol\u00e8cules <em>Notch<\/em> i<em> Dll4<\/em><\/strong>, que les c\u00e8l\u00b7lules expressen a la seva superf\u00edcie, \u00e9s vital. \u00ab<strong>Si es bloqueja<\/strong> la interacci\u00f3 cel\u00b7lular entre ambdues prote\u00efnes, cosa que hem fet amb anticossos dissenyats per a bloquejar la prote\u00efna Dll4, <strong>es potencia<\/strong> el fet que les c\u00e8l\u00b7lules es converteixin en <strong>c\u00e8l\u00b7lules mare hematopo\u00e8tiques<\/strong>\u00ab, explica Bigas.<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p>L&#8217;equip cient\u00edfic ha mostrat que la bloquejar la interacci\u00f3 entre les mol\u00e8cules <strong><em>Notch<\/em> i<em> Dll4\u00a0<\/em><\/strong>potencia que les c\u00e8l\u00b7lules es converteixin en c\u00e8l\u00b7lules mare hematopo\u00e8tiques.<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p>En l\u2019estudi, dirigit des de <a href=\"https:\/\/ellipse.prbb.org\/ca\/trobada-anual-de-limim-compartir-per-enfortir-la-recerca\/\" target=\"_blank\" rel=\"noopener\">l&#8217;IMIM<\/a>, hi han participat tamb\u00e9 investigadors de la\u00a0<strong>Universitat de Tel Aviv<\/strong>, de la\u00a0<strong>Universitat d&#8217;Edimburg<\/strong>, de la\u00a0<strong>Universitat de la Sorbona de Par\u00eds i de la de Cambridge.<\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Poder generar c\u00e8l\u00b7lules mare de la sang al laboratori ser\u00eda un pas enorme en el camp de la medicina regenerativa, i concretament en el tractament de pacients amb malalties com la leuc\u00e8mia o patologies gen\u00e8tiques que afecten la sang i que no tenen un donant compatible. Aquesta imatge pertany a un recent estudi que podr\u00eda [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":13365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,213,323],"new-type":[40],"class_list":["post-13364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-imim","tag-microscopia","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=13364"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13364\/revisions"}],"predecessor-version":[{"id":13447,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/13364\/revisions\/13447"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/13365"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=13364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=13364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=13364"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=13364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}