{"id":12587,"date":"2020-02-12T13:09:25","date_gmt":"2020-02-12T12:09:25","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=12587"},"modified":"2020-02-12T13:16:00","modified_gmt":"2020-02-12T12:16:00","slug":"nou-element-clau-en-la-regulacio-dels-interferons-durant-la-resposta-immunologica","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/nou-element-clau-en-la-regulacio-dels-interferons-durant-la-resposta-immunologica\/","title":{"rendered":"Nou element clau en la regulaci\u00f3 dels interferons durant la resposta immunol\u00f2gica"},"content":{"rendered":"

Quan una c\u00e8l\u00b7lula \u00e9s infectada per un virus, aquesta secreta\u00a0interferons<\/strong>, que s\u00f3n\u00a0reguladors clau en la defensa antiviral<\/strong>. Per\u00f2 aquests ‘herois’ poden acabar sent un problema: un exc\u00e9s d’interferons pot induir l’aparici\u00f3 de malalties inflamat\u00f2ries i autoimmunes. Tamb\u00e9 pot provocar una sobre-activaci\u00f3 de c\u00e8l\u00b7lules mare<\/a> hematopo\u00e8tiques i, conseq\u00fcentment, la desparici\u00f3 de les mateixes (les c\u00e8l\u00b7lules mare han de romandre en un estat quiescent, \u00e9s a dir, descansant en mode ‘reserva’, preparades per auto-activar-se quan es necessitin noves c\u00e8l\u00b7lules).<\/p>\n

Per aix\u00f2,\u00a0\u00e9s essencial poder regular amb precisi\u00f3 l’expressi\u00f3 dels interferons<\/strong>.<\/p>\n

La col\u00b7laboraci\u00f3 de dos grups de recerca del\u00a0Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (DCEXS-UPF)<\/a>\u00a0\u2014 un liderat per Cristina L\u00f3pez-Rodr\u00edguez i Jose Aramburu<\/a>, i l’altre per Andreas Meyerhans<\/a>\u00a0\u2014 ha dut al recent descobriment d’un nou element<\/a> en la regulaci\u00f3 dels interferons. Utilitzant ratolins\u00a0knock-out<\/em> per\u00a0NFAT5<\/strong>\u00a0(\u00e9s a dir, ratolins als quals els hi falta aquest gen) van trobar que aquesta mol\u00e8cula, coneguda per activar l’expressi\u00f3 de molts gens inflamatoris,\u00a0inhibeix l’expressi\u00f3 dels interferons<\/strong>.<\/p>\n

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Hector Huerga, primer autor i estudiant de doctorat al DCEXS<\/a>, comenta que \u00abNAFT5 s’uneix a la regi\u00f3 reguladora d’interferons a la mateixa \u00e0rea on ho fa IRF3, un inductor d’interferons\u00bb. Per tant,\u00a0NAFT5 competeix amb IRF3 per la mateixa regi\u00f3<\/strong>, i aquesta competici\u00f3 \u00e9s el que realment\u00a0controla els nivells d’interferons<\/strong>, assegurant una resposta a l’atac viral sense comprometre la reserva de c\u00e8l\u00b7lules mare de la sang<\/a>.<\/span><\/p>\n

Huerga, que actualment est\u00e0 cursant el seu post-doctorat a l’Institut Crick<\/a> de Londres, afegeix: \u00absovint veiem que \u00e9s necessari que qualsevol resposta immunol\u00f2gica disposi d’un ‘fre’, i aix\u00ed evitar que aquesta resposta sigui excessiva. Aquesta \u00e9s una forma de protegir-nos de malalties causades per la sobreproducci\u00f3 de mediadors inflamatoris.\u00bb<\/p>\n

L’estudi es va portar a terme utilitzant ratolins com animals model<\/a>, aix\u00ed com cultius de c\u00e8l\u00b7lules humanes<\/a>.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Els interferons s\u00f3n reguladors clau de les defenses antivirals, per\u00f2 en exc\u00e9s tamb\u00e9 poden ser perillosos. Dos grups de recerca del DCEXS-UPF han trobat una nova mol\u00e8cula implicada en regular la seva expressi\u00f3.<\/p>\n","protected":false},"author":9,"featured_media":12204,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[411,679,273,221,475],"new-type":[35],"class_list":["post-12587","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-immunologia","tag-infeccio","tag-melis-upf-ca","tag-ratoli","tag-virus-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/12587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=12587"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/12587\/revisions"}],"predecessor-version":[{"id":12660,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/12587\/revisions\/12660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/12204"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=12587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=12587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=12587"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=12587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}